England v Australia

Venue: Twickenham Dates: 3 October

Coverage: Live on BBC Radio 5 live, plus live text commentary on BBC Sport website.

Australia have suffered a setback in their preparations for Saturday's Pool A match against England as forwards Will Skelton and Wycliff Palu have been ruled out of the World Cup.

Powerful lock Skelton, 23, sustained a pectoral injury during the Wallabies' 65-3 victory over Uruguay on Sunday.

Number eight Palu, 33, injured his hamstring in the match and will be replaced by hooker James Hanson, 27.

Lock Sam Carter, 26, will replace Skelton in the squad.

Australia coach Michael Cheika told the team's official website:  "Very few players have the opportunity to play for the Wallabies, let alone at a Rugby World Cup, so from that perspective I'm really gutted for them.

"From a team perspective, they both play important roles in the side and it is disappointing that we need to replace players in our squad.

"Both James and Sam have been part of the team at various stages this season and I am confident they will be able to step up and grasp the opportunity they have been given."

Australia, who also comfortably won their opening game against Fiji 28-13, face their first major test on Saturday when they play England at Twickenham in a must-win match for Stuart Lancaster's side.

Coach Cheika surprised many by only naming two hookers in his 31-man squad, but has decided not to replace Palu with another back-rower, instead calling on Hanson, who flew out from Australia on Monday.

Palu's injury means he could have played his final game for the Wallabies as he has signed to play in Japan next season and falls three caps short of Australia's 60-cap threshold for overseas-based internationals.

The loss of Skelton, who weighing 140kg was the second heaviest player at the tournament, is a significant one for Australia as his ball-carrying ability will be missed.

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